In these studies, we have demonstrated two key findings in patients with IHD: (1) HH has a neutral effect on LV function during dobutamine stress; and (2) in patients with T2DM, an intravenous infusion of GLP-1(7-36) amide at the time of hyperglycemia enhances myocardial performance during dobutamine stress. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.