At peak stress, there was a greater increase in LV function after GLP-1 infusion during hyperglycemia (77.5 ± 5.0 [GLP-1 HHC] versus 71.3 ± 4.3% [control HHC], p = 0.004), and this improved performance persisted into recovery (59.6 ± 3.6 [GLP-1 HHC] versus 50.1 ± 5.8% [control HHC], p < 0.0001). Here, GLP1R is linked to Hyperglycemia.