Furthermore, we found that AP-1 and NF-κB transactivation activities were downregulated by the inhibition of ERK1/2-mediated RSK2 activity [5, 20], suggesting that magnolin may suppress the gene expression of Cox-2, an enzyme that plays an important role in cancer cell proliferation, motility and metastasis [24]. The gene discussed is NFKB1; the disease is cancer.