RPS6KA3 and cancer: The ERKs/RSK2 signaling axis plays a pivotal role in cell proliferation, differentiation, survival, and transformation [8, 10, 13, 15, 21], in addition to cell migration through the induction of matrix metalloproteinases (MMPs), which are the enzymes that degrade the extracellular matrix, such as collagen and gelatin, to facilitate the metastasis of cancer cells [6].