LRG1 was assayed by ELISA and reported to have an increased fold change and predictive ability for CRC detection in a cohort of 58 subjects with CRC and 58 control subjects, and also in a pre-diagnosis cohort of 32 female subjects with CRC and 32 female control subjects (Ladd et al, 2012). The gene discussed is LRG1; the disease is colorectal carcinoma.