Therefore, the aim of this study was to evaluate periodontal status in reference to a single-nucleotide polymorphism (SNP) of NLRP2: F359L (rs17699678 C>T) and NLRP3: Q705K (rs35829419 C>A) in patients with pancreatic cancer and chronic pancreatitis as well as in the control group. The gene discussed is NLRP3; the disease is chronic pancreatitis.