On the contrary, before us Maioli et al. found that BMI, number of positive autoantibodies and HLA DRB1-DQB1 genotypes at high risk for type 1 diabetes were associated with the progression towards insulin requirement [28], but the association between GADA and insulin therapy was not significant after a follow-up period of four years as well as in the UKPDS 77 after a follow-up of 6 years [29]. Here, INS is linked to type 1 diabetes mellitus.