CLEC4C and melanoma: Here, repetitive DT injections were administered up to 15 days and flow cytometry analysis of spleen and dermis at day 15 depicted over 90% reduction of pDCs in both organs.[26] Further, successful pDC ablation in spleen and lymph node of BDCA2-DTR mice was also reported in a mouse melanoma model, however in this study cells were only depleted for 6 days.[34] In summary, data sufficiently supporting sustained pDC depletion in BDCA2-DTR mice for more than two weeks have not yet been published.