One such cell line is the cytokine-dependent CD34+ MUTZ-3 monocytic acute myeloid leukemia (AML) cell line, which has previously been used as a sustainable model to study human DC differentiation and maturation (interstitial DC-like [IDC] and Langerhans cells [LC]) in vitro [15–18]. This evidence concerns the gene CD34 and acute myeloid leukemia.