In our study, the cellular distribution of β-catenin is partially shifted to nucleus in HCC samples (Fig 2H) compared with the normal PLTs, and the overexpression of IQGAP1 promotes β-catenin translocation to nucleus in HepG2 cells (Fig 3E), which both are consistent with the previous reports. The gene discussed is IQGAP1; the disease is hepatocellular carcinoma.