In the propensity-score matching analysis which included age, gender, Child-Pugh class, performance status, initial AFP level (≤400 ng/mL vs. >400 ng/mL), viral etiology, tumor size, sites of PVTT, and stage, AFP response remained a significant prognostic factor for OS (AFP responder, HR = 0.264, p < 0.001) and PFS (AFP responder, HR = 0.307, p < 0.001) (Table 4). Here, AFP is linked to neoplasm.