TLE5 and cystic fibrosis: Previous reports suggest that mutational deactivation of hmgA and pyomelanin overexpression is associated with chronic P. aeruginosa strains infecting CF patients [17], however chronic infection isolates of AES-1 still express hmgA (Table 1) and no pyomelanin, indicating putative regulatory control of hmgA in chronic P. aeruginosa AES-1 to suit the host environment rather than adaptive mutation.