Among these, 13 full texts remained for eligibility evaluation, of which 8 publications were finally excluded for focusing on cancer risk and other polymorphisms of NFKBIA gene.4,15–17,28–31 Therefore, our final data pooling consisted of 5 case-control studies19–23 involving 1965 cancer cases and 2717 cancer-free controls (Figure 1). The gene discussed is NFKBIA; the disease is cancer.