TNF and nervous system disorder: The latter finding is intriguing given the proclivity of TNF-inhibitors to induce autoantibodies.179–182 The spectrum of neurological disorders which may be attributable to TNF-inhibitors is broadening.179,181 In other TNF-inhibitor-induced, neurological disorders, there may be improvement, arrest, or further deterioration upon withdrawal of TNF-inhibitors.179,183 Our patient demonstrated disease progression despite withdrawal of TNF-inhibitor therapy.