TNF and Behcet disease: Table 2D describes that there were 7 reports of ALS in 14 rheumatic disease patients, including 2 patients with SLE,127,128 5 patients with Behcet's syndrome,129 4 patients with RA who were not on TNF-inhibitor therapy,130,131 and 3 patients (1 with ankylosing spondylitis and 2 with RA) with ALS developing in the context of TNF-inhibitor therapy.130,132,133 Three patients presented with abnormal MRI findings,128–130 but with lesions which were not spatially disseminated, and therefore could not account for a diffuse ALS-plus presentation.