The results demonstrated that in these 308 cases of NSCLC, TGFβR2 expression levels were positively correlated with tumor differentiation (P = 0.029) and invasion of the lung membrane (P = 0.045) as well as chemotherapy (P < 0.001; Table 2).However, there was no association between TGFβR2 expression and patient gender, age, smoking history, lymph-node metastasis, histology, vascular invasion, TNM stage, or tumor diameter (P >0.05). Here, TGFBR2 is linked to metastatic malignant neoplasm in the lymph nodes.