To differentiate between the roles of IFNα and IFNβ we investigated the effect of pICLC administration on survival of Ifnb-/- mice following infection with C. neoformans. Importantly, pICLC treatment protected IFNβ deficient mice infected with H99 (Fig 1F), suggesting a possible role of IFNα in the pICLC induced protection against cryptococcal infection. The gene discussed is IFNB1; the disease is infection.