Eleven percent of the samples from HNSCC tumors were hypermethylated on all three genes of Galanin, GALR1 and GALR2, 19% of those tumors were hypermethylated two of three genes, 22% were hypermethylated only a single gene, and 48% were did not methylate any gene [61]. Here, GALR2 is linked to head and neck squamous cell carcinoma.