IL-17 induces endothelial cell activation, expression of endothelial adhesion molecules, followed by adhesion and infiltration of neutrophils [256], providing the rational for beneficial effects of therapy with a soluble TNF-α receptor antibody (etanercept) on angiotensin-II induced vascular superoxide production and hypertension [257,258]. The gene discussed is AGT; the disease is Hypertension.