For example, while the transfection of rodent fibroblast cells with Src and Ras oncogenes reduces the adhesiveness to fibronectin (Fn) by impairing α5β1 integrins, the activation of oncogene ErbB2 in breast cancer up-regulates α5β1 integrin and enhances adhesion [13,14]. The gene discussed is FN1; the disease is breast carcinoma.