Plasma levels of D-dimer and TAT complexes either normalized or decreased close to normal in both patients (Fig. 1d), further indicating that plasma D-dimer may be an appropriate marker of systemic coagulation activation in newly diagnosed AML, particularly in the absence of recent surgery, acute infections, and relevant organ dysfunctions, all of which were exclusion criteria in our study (see section “Methods”). Here, TAT is linked to acute myeloid leukemia.