TF and acute myeloid leukemia: In the total AML patient cohort (n = 69), TF PCA was significantly increased in disrupted as compared to intact PBMCs (median TF PCA, 696 vs. 293 AU/106 cells, P < 0.001) (Fig. 1a), indicating that a significant proportion of the TF PCA was latent (or cryptic) on unperturbed cells.