In the total AML patient cohort (n = 69), plasma levels of D-dimer significantly correlated with TF PCA of intact (Fig. 2a) and disrupted PBMCs (Fig. 2b), absolute numbers of circulating blasts (Fig. 2c), and lactate dehydrogenase (LDH) serum levels (Fig. 2d). This evidence concerns the gene TF and acute myeloid leukemia.