Recently, several reports on preclinical studies demonstrated that Syk inhibition might represent a rational therapeutic target in B cell malignancies such as chronic lymphocytic leukaemia (CLL), diffuse large B-non-Hodgkin lymphoma (DLBCL), follicular and mantle cell lymphoma by interfering with the signalling promoted by the activation via the BCR, cytokines and stromal factors [27–29]. This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.