Both groups had the same values for diuresis, renin and creatinine clearance at 24 h. Animals with obstructive jaundice had lower sodium concentration and an increase in aldosterone levels (P < 0.03), endothelin-1 (P < 0.001) and prostaglandine E2 (P < 0.001) in urine. Here, REN is linked to obstructive jaundice.