Closer inspection using stratified GSEA, however, revealed that, for several mouse phenotypes, psoriasis-like changes in DEGP expression were primarily driven by activation of non-specific rather than psoriasis-specific responses (e.g., D6-KO, K5-Stat3c and K14-ADAM17-KO; Additional file 18b). This evidence concerns the gene ACKR2 and psoriasis.