ISG15 and psoriasis: Of the most psoriasis-specific DEGPs, the majority were induced by IL-17A (e.g., FERMT1, GLUL, SULT2B1; Fig. 6b); in contrast, the most non-specific DEGPs were not disproportionately induced by IL-17A and several were repressed (e.g., AKR1B10, RNF213, ISG15; Fig. 6c).