Differences among top-ranked mouse phenotypes were minor, but the most psoriasis-like changes in DEGP expression were observed in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated mice lacking chemokine decoy receptor D6 (D6-KO) [69], mice with KC-specific overexpression of the angiopoietin receptor Tie2 (K5-Tie2) [70], and mice with K14-driven deletion of GlcCer-synthesizing enzyme UDP-glucose:ceramide glucosyltransferase (UGCG; K14-Ugcg-KD) [71] (Additional file 17f). This evidence concerns the gene KRT5 and psoriasis.