DEGPs showed psoriasis-like changes in expression when KCs were treated with cathelicidin antimicrobial peptide (LL37) or scratched (wounded) in culture; conversely, DEGPs showed psoriasis-opposite changes in expression when KCs were treated with human papillomavirus oncoprotein E6, heparanase inhibitor (BIPBIPU) or dexamethasone (Additional file 17c). The gene discussed is HPSE; the disease is psoriasis.