Although the effects in the genetic models was substantial, this or related strategies are rather of academic value in CMT models rather than a realistic option in the nonfatal inherited neuropathies, as the MEK‐ERK pathway is pleiotropically involved in a variety of cell biological processes and thus side effects have to be expected by long term inhibition of this pathway. The gene discussed is MAP2K7; the disease is Charcot-Marie-Tooth disease.