Fig 5A and 5B indicate that in the absence of extracellular calcium, CML-HSA pretreatment affected the basal calcium levels (52.9±2.8 nM) compared with PBS (68.2±3.9 nM). Moreover, Fig 5A and 5C indicate that AVP-induced calcium released from the sarcoplasmic reticulum was also increased by CML-HSA pretreatment (135±14 nM) compared with PBS (60.6±15.9 nM). Remarkably, whereas calcium entry (Fig 5A and 5D) was decreased in the cells pretreated with AGE-HSA (7.0±0.8 nM), it was increased in the cells pretreated with CML-HSA (25.2±5.4 nM) compared with the control (12.6±3.8 nM). Here, ALB is linked to chronic myelogenous leukemia, BCR-ABL1 positive.