Interestingly, SPARC-dependent modulation of cell size was not restricted to melanoma cells; indeed, enforced expression of SPARC in SPARC-negative pancreatic cancer cells reduced cells’ volume by 55% to 65% (Fig 4B), confirming that SPARC has the ability to control cell size at least in different malignant cell types. Here, SPARC is linked to pancreatic neoplasm.