DCN and neoplasm: Furthermore, OKN-007 was able to significantly decrease the immunoexpression of PDGFRα (p < 0.05) and significantly increase the expression of decorin (p < 0.05) in responsive IC-3752GBM pGBM tumor bearing mice, compared to untreated animals, which may be also associated to the inhibition of tumor angiogenesis and cell proliferation which was also observed in the OKN-007-R treated animals from this study.