SULF2 and hepatocellular carcinoma: Support for the anti-cancer effect of OKN-007 via the TGFβ1 pathway was recently reported by Zheng et al. (2013), where they found that OKN-007 mediates its antitumor effect in HCC cells (Huh7) via the suppression of TGFβ1/SMAD2 and Hedgehog/GLI1 signaling by inhibiting sulfatase 2 (SULF2) enzymatic activity [19].