Remarkably, we found that silencing of Rab35 led to a significant reduction in the intracellular bacterial load of BEC5637 cells at 24 and 48 h post infection (3.3 fold at 24 h, p = 0.01 and 2.5 fold at 48 h, p = 0.04) (Fig 2A). The gene discussed is RAB35; the disease is infection.