In neurodegeneration, EVs are also partially responsible by the transmission of misfolded pathogenic forms of proteins, such as Abeta and tau associated with Alzheimer’s disease, alpha-synuclein associated with Parkinson’s disease, and superoxide dismutase associated with amyotrophic lateral sclerosis [49,56], among cells. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.