Impairment of autophagic flux by B10, a derivative of betulinic acid was also reported to convert autophagy in glioblastoma cells into a cell death process associated with lysosomal destabilization [55] and the anti-tumour activity of recombinant Galectin 9 was also associated with impairment of lysosomal function and fatal frustration of autophagy [56]. Here, LGALS9 is linked to neoplasm.