PIK3CA and ovarian clear cell cancer: Clear cell ovarian carcinomas, on the other hand, typically express wild-type p53 but contain ARIDIA and PI3K aberrations, which often originate from endometriosis [6]; similarly, low-grade SOC also express wild-type p53 but contain KRAS or BRAF mutations and may be derived from serous borderline ovarian tumors [7, 8].