Similarly, myocardial mRNA content of both UCP2 and UCP3 were increased in LPS-induced endotoxemia in rats, and increased myocardial mRNA and protein expression of UCP2 was observed in a canine model of endotoxin-induced shock associated with decreased phosphocreatine/ATP ratios [41,58]. This evidence concerns the gene UCP3 and serum lipopolysaccharide activity.