PIK3CA and tumor of salivary gland: Importantly, several possible biological targets in salivary gland tumors have been reported: c-Kit[11] (positive protein expression by immunohistochemistry but no exon 11 or 17 mutations); EGFR [12], HER2 [13, 14], androgen, estrogen and progesterone receptor protein expression by immunohistochemistry [15]; and PIK3CA [16] and BRAF mutations [16].