However, Gomez-Ambrosi [9] reported that serum betatrophin concentrations were decreased in patients with obesity and T2DM and Fenzl [10] reported that serum betatrophin presented no correlation with different glucose tolerance status but correlates with lipid profiles in patients with obesity or T2DM. Here, ANGPTL8 is linked to obesity due to melanocortin 4 receptor deficiency.