PLAT and Stroke: The National Institute of Neurological Disorders and Stroke (NINDS) trials have demonstrated the efficacy of recombinant tPA treating AIS of all subtypes within 3 hours of stroke onset.[2–5] One cohort study reported that the rate of complete recanalization at 6 hours was higher (P = 0.006) in patients with cardioaortic embolic (CE) stroke compared to those with other stroke subtypes [6].