No mutations in the EGFR, PTEN and PIK3CA genes or EML4-ALK fusions were found in the panel of LCSC lines analyzed (Table 1a); LCSCs 4 and 6 (SCC and ADC, respectively) displayed KRAS G12C (Table 1a,Supplementary Table 2 and Supplementary Information). Here, PIK3CA is linked to AIDS dementia complex.