Recent studies demonstrated feasible evidence suggesting a role for ER stress in the development of renal fibrosis in the setting of patients with CKDs.18 Given the role of CHOP had in the induction of ER stress, we thus hypothesized that CHOP may have a critical role in the pathogenesis of renal fibrosis secondary to CKDs. This evidence concerns the gene DDIT3 and renal fibrosis.