PTPA and colorectal cancer: Despite advances in chemotherapy, drug resistance is still one of the biggest obstacles for treating advanced colorectal cancer effectively.49 Therefore, the discovery of miR-587 as a contributing factor of drug resistance and the identification of the regulatory miR-587/PPP2R1B (PP2A)/pAKT/XIAP signaling axis may facilitate to design strategies to increase the overall efficacy of chemotherapy of colorectal cancer.