NOS1 and Cerebral ischemia: NMDARs have well-established roles in traumatic brain injury and cerebral ischemia,30, 31 and a number of inhibitors targeting NMDAR-PSD95-nNOS complexes have been thoroughly investigated.32, 33, 34, 35, 36, 37 In the present study, we successfully established in vivo and in vitro NMDA injury models.