TP53 and neoplasm: The human TIGAR possesses two p53-binding sites, human p53-binding site (hBS) 1 and hBS2, where hBS2 is the functional p53-binding site.2 In the mouse genome, Tigar shows a similar organisation with two potential p53-binding sites, mBS1 and mBS2, in a similar arrangement as human TIGAR. 10 As a p53 target, TIGAR would be predicted to play a role in tumour suppression and the antioxidant functions of TIGAR would be consistent with a role in protecting from the acquisition of damage.