Previous studies reported that oxidative stress is associated with DRP1-mediated mt fission and dysfunction in hypertension-induced brain injury41 as well as hyperproliferation of vascular smooth muscle cells in pulmonary arterial hypertension.42 Of interest, our present findings showed that blocking oxidative stress by CoQ10 treatment significantly decreased total DRP1 protein expression but not DRP1 S616 phosphorylation in the retina of glaucomatous D2 mice. The gene discussed is DNM1L; the disease is hypertensive disorder.