In contrast, hnRNP A1 levels and its cytoplasmic accumulation are increased in numerous cancers, and hnRNP A1 is a direct target of an anticancer drug quercetin.28 HK2 is overexpressed in cancer cells, is a major contributor to the Warburg effect, and specific targeting of HK2 shows therapeutic promise for the treatment of cancer.27 Our data propose a novel link whereby HK2 activity contributes to the cytoplasmic accumulation of hnRNP A1. This evidence concerns the gene HK2 and cancer.