MAVS and hepatocellular carcinoma: Specifically, an eAFP-VISA-BikDD vector was designed to induce targeted expression of BikDD in HCC cells by controlling its expression under a liver cancer-specific α-fetoprotein promoter/enhancer (eAFP), whose activity can further enhanced by the VP16-GAL4-WPRE integrated systemic amplifier (VISA) module [25, 26] to a level similar or comparable to that of the non-specific cytomegalovirus (CMV) promoter.