Chronic inflammation, the basic feature of rheumatoid arthritis (RA), plays a major role in accelerated atherosclerosis in patients with RA through its influence on insulin resistance, lipid status, and atherothrombogenic factors, such as fibrinogen, D-dimer, von Willebrand factor (vWF), and plasminogen activator inhibitor (PAI) [4]. This evidence concerns the gene SERPINB2 and atherosclerosis.