In the postmenopausal subgroup, tumor PELP1 correlated with E1 and E2 concentrations in normal tissue (r = 0.543, P = 0.003 and r = 0.601, P = 0.001, Fig 1A and 1B, respectively) and plasma (r = 0.392, P = 0.053 (borderline significance) and r = 0.403, P = 0.046, Fig 1C and 1D, respectively). The gene discussed is PELP1; the disease is neoplasm.