ACVRL1 and pulmonary arterial hypertension: 2011). We designed target-specific oligonucleotides to capture all coding exons, exon-intron boundaries, and known intronic mutations in the PAH-associated target genes. All these target genes were comprehensively analyzed using OS-Seq. These 21 Finnish PAH patients had been previously tested for mutations in the BMPR2 and ACVRL1 genes using Sanger sequencing (Sankelo et al. 2005). With OS-Seq we detected all previously identified pathogenic or likely pathogenic variants of BMPR2 gene and identified two new pathogenic BMPR2 variants that were previously missed using Sanger sequencing.