Given the characteristic time-space clustering and the expression of proinflammatory and profibrotic cytokines both in the liver and in the circulation, including interleukin-6 (IL-6) and interleukin-8 (IL-8), isolated BA is believed by some to be secondary to hepatobiliary viral infection [3, 4]. This evidence concerns the gene CXCL8 and breast angiosarcoma.