A growing number of investigations have implicated a role for HMGB1 in fibrotic diseases, with increased levels of HMGB1 in patients that have systemic sclerosis [123, 130], cystic fibrosis [131, 132], liver fibrosis [133], or pulmonary fibrosis [134, 135]. The gene discussed is HMGB1; the disease is systemic sclerosis.