During the second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium in 2006, the need was identified to further investigate the pathophysiological mechanisms and appropriate treatment of anaphylactoid or pseudoallergic reactions, fulfilling the diagnostic criteria for anaphylaxis with no involvement of an IgE-mediated mechanism.5 Here, IGHE is linked to anaphylaxis.