Similarly the individuals withobesity exhibit a significant increase in GFR (22).In our study, GFR was also significantly higher inPCOS group in multiple regression analysis includingBMI, HOMA-IR, glucose, and insuline.Lakhani et al. (27) has shown that there was nodifference in GFR between women with PCOSand controls (102.2 vs. 114.4 ml/min per 1.73 m2).However, 15 PCOS patients were included in theirstudy. This evidence concerns the gene INS and polycystic ovary syndrome.