LEP and obesity due to melanocortin 4 receptor deficiency: Deficiency of leptinor its receptors, in addition to causing obesity,leads to disturbing reproductive cycle, hormonalimbalance, as well as disorders of immune system,hematopoietic system and bone metabolism (8).These observations have indicated the importantrole of leptin in several physiologic processes andthe relationship between abnormal leptin levelsand many disorders (9).