LEP and Infertility: Since it has been proved that there is a definiterelationship between infertility and menstrual irregularitiesin women with abnormal obese (OB)gene expression and peritoneal fluid is also knownas an active biologic environment that is essentialfor regulation of ovarian function, ovulation, zygoteimplantation, and follicle collection (9, 11),any change in the concentration of substances inthis environment is likely to affect ovarian function.Furthermore it can be postulated that the originof some substances like leptin might be fromfollicular fluid.