Therefore, if dietary interventions could reduce the chronic systemic exposure of postprandial hypertriglyceridemia by modulating, in part, intestinal DGAT1 activity without significant and intolerable gastrointestinal side effects, this could be a potential dietary strategy to improve multiple cardiovascular and metabolic risks linked to postprandial hypertriglyceridemia. Here, DGAT1 is linked to hypertriglyceridemia.